SSNRI stands for Selective Serotonin-Norepinephrine Reuptake Inhibitor.


SSNRI is a class of antidepressant medications that primarily work by inhibiting the reuptake of both serotonin and norepinephrine in the brain. They are commonly prescribed to treat major depressive disorder, anxiety disorders, and certain other mental health conditions.

Mechanism of Action:

SSNRIs prevent the reuptake of serotonin and norepinephrine neurotransmitters by blocking their transporters, thus increasing their availability in the brain. By enhancing the levels of these neurotransmitters in neural synapses, SSNRIs are believed to improve mood, alleviate depressive symptoms, and regulate emotional balance.

Common SSNRIs:

Some commonly prescribed SSNRIs include:

  • Venlafaxine (Effexor)
  • Duloxetine (Cymbalta)
  • Desvenlafaxine (Pristiq)
  • Levomilnacipran (Fetzima)


SSNRIs are typically prescribed for the following conditions:

  • Major depressive disorder
  • Generalized anxiety disorder
  • Panic disorder
  • Social anxiety disorder
  • Post-traumatic stress disorder (PTSD)
  • Obsessive-compulsive disorder (OCD)
  • Fibromyalgia

Safety and Side Effects:

While SSNRIs are generally considered safe and well-tolerated, they may cause certain side effects, including:

  • Nausea
  • Headache
  • Drowsiness
  • Dizziness
  • Insomnia
  • Dry mouth
  • Constipation
  • Increased sweating

It is important to consult a healthcare professional for appropriate dosage, potential drug interactions, and to discuss any possible risks or concerns.