Somatotropin, also known as growth hormone (GH), is a peptide hormone produced by the somatotrophic cells of the anterior pituitary gland in the brain.


Somatotropin plays a crucial role in regulating growth, cell reproduction, and regeneration in humans and animals.

Production and Release:

GH is secreted into the bloodstream in pulsatile bursts throughout the day, with the highest levels typically occurring during sleep.


Somatotropin release is primarily stimulated by the hypothalamus, specifically by the hormone growth hormone-releasing hormone (GHRH).

Target Cells and Effects:

GH acts on a wide variety of tissues and cells in the body, including bone, muscle, liver, and adipose (fat) tissue.

Some of its effects include promoting growth in children, maintaining bone density and muscle mass in adults, stimulating protein synthesis, regulating metabolism, and participating in the immune response.

Disorders and Deficiencies:

Abnormal GH levels can lead to various disorders, such as acromegaly (excessive GH production in adults) or pituitary dwarfism (insufficient GH production in children).