Definition of Secondary Hyperaldosteronism

Secondary Hyperaldosteronism is a medical condition characterized by the excessive production and secretion of aldosterone, a hormone primarily responsible for regulating salt and water balance in the body, as a result of a non-primary adrenal gland disorder.


The condition occurs when there is an underlying issue affecting the adrenal glands, such as:

  • Renal artery stenosis: Narrowing of one or both renal arteries, reducing blood flow to the kidneys.
  • Congestive heart failure: A condition where the heart does not pump blood effectively, causing fluid retention and decreased kidney function.
  • Nephrotic syndrome: A kidney disorder causing abnormal levels of protein in the urine and low levels of protein in the blood.
  • Cirrhosis of the liver: Scarring of the liver, leading to inadequate blood filtration and fluid imbalance.


The signs and symptoms of secondary hyperaldosteronism can include:

  • High blood pressure (hypertension)
  • Fluid retention and swelling (edema)
  • Low potassium levels (hypokalemia)
  • Increased urine production
  • Fatigue and muscle weakness


The treatment approach for secondary hyperaldosteronism depends on addressing the underlying cause. Treatment options may include:

  • Medications to control blood pressure and reduce aldosterone production
  • Surgical interventions for conditions like renal artery stenosis
  • Managing the underlying condition, such as controlling heart failure or cirrhosis
  • Dietary changes, with increased potassium intake to restore balance

It is important for individuals with secondary hyperaldosteronism to work closely with their healthcare providers to effectively manage and treat the condition, as well as to monitor blood pressure and electrolyte levels regularly.