Azathioprine

Azathioprine is a medication that belongs to the class of immunosuppressive drugs.

Uses

• 1. Treatment of autoimmune diseases
• 2. Prevention of organ rejection in transplant recipients

Mechanism of Action

Azathioprine works by inhibiting the production of DNA and RNA, which reduces the proliferation of immune cells and suppresses the immune system’s response.

Side Effects

• 1. Nausea and vomiting
• 2. Diarrhea
• 3. Increased risk of infections
• 4. Liver toxicity
• 5. Bone marrow suppression

Contraindications

• 1. Hypersensitivity to azathioprine
• 2. Severe hepatic or renal impairment
• 3. Pregnancy (unless benefits outweigh risks)

Drug Interactions

Azathioprine may interact with the following medications:

• 1. Allopurinol
• 2. ACE inhibitors
• 3. Warfarin
• 4. ACE inhibitors
• 5. Angiotensin receptor blockers

Dosage and Administration

The dosage of azathioprine varies depending on the specific condition being treated, the patient’s weight, and other factors. It is important to follow the prescribed dosage and administration instructions provided by the healthcare professional.

Warnings and Precautions

Before taking azathioprine, it is important to consider the following precautions:

• 1. Regular monitoring of blood counts and liver function
• 2. Increased susceptibility to infections
• 3. Not recommended during breastfeeding
• 4. Increased risk of malignancy

Conclusion

Azathioprine is an immunosuppressive medication commonly used in the treatment of autoimmune diseases and to prevent organ rejection after transplantation. It works by suppressing the immune system. However, it may pose certain side effects and drug interactions, and caution should be exercised when using this medication.