Amyloids
Amyloids are insoluble fibrous protein aggregates that accumulate in extracellular spaces in various tissues and organs.
Formation of Amyloids
Amyloids are formed when proteins undergo a conformational change, leading to the aggregation and accumulation of misfolded proteins.
Structure of Amyloids
Amyloids typically exhibit a cross-beta sheet structure, where individual protein molecules stack together to form elongated fibrils.
Associations with Diseases
Amyloid deposition is commonly associated with certain neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and prion diseases.
Diagnostic Tools and Techniques
Various diagnostic tools and techniques, including histological staining, immunohistochemistry, and imaging techniques, are used to detect and visualize amyloid deposits in tissues.
Therapeutic Approaches
Several therapeutic approaches, such as immunotherapy, small molecule inhibitors, and gene therapies, are being investigated for the treatment and prevention of amyloid-related diseases.